In 2006, Mizanin became host of the annual WWE Diva Search competition and began wrestling on the main roster. Mizanin was drafted to the ECW brand in 2007, where he formed a successful partnership with John Morrison, winning the WWE Tag Team Championship, World Tag Team Championship, and the 2008 Tag Team of the Year Slammy Award. After being drafted to Raw in 2009, he won the United States Championship twice, the unified tag team titles with Big Show and the Raw Money in the Bank ladder match for a guaranteed WWE Championship match. He cashed it in to win the WWE Championship in November 2010 and went on to hold for six months, including a successful defense against John Cena in the main event of 2011's WrestleMania XXVII. That year, he was ranked number one on Pro Wrestling Illustrated's annual PWI 500 list. Mizanin largely dropped out of world title contention after 2011, and the period of 2012 to 2017 has been marked by him winning the Intercontinental Championship seven times, which made him the 25th Triple Crown Champion in company history and the 14th Grand Slam Champion.